Brief profile
Alessandro Castagna, M.D.
- Specialized in Orthopaedics and Traumatology
- Master's degree in Neuro Psycho Physical Pathology and in Neuro Psycho Physical Optimization.
- Specialization Course in Neuro Psycho Respiratory Optimization - Neuro Psycho Kinesis Therapy.
Current positions
- Secretary of the Society of Neuro Psycho Physical Optimization
Dr. Alessandro Castagna does not perform his clinical activity within the Rinaldi Fontani Institute, but he is an integral part of the medical staff of the Institute, thanks to his constant commitment in research, training and teaching in the specialization courses of specialization in Neuro Psycho Physical Optimization held at the Institute in Florence.
Speaker at national and international conferences.
Publications on international journals indexed in PubMed
Physical stimulation by REAC and BMP4/WNT-1 inhibitor synergistically enhance cardiogenic commitment in iPSCs. Basoli V, Santaniello S,Rinaldi S, Fontani V, Pigliaru G, Wieser M, Strajeriu A, Castagna A, Redl H, Ventura C, Grillari R, Maioli M.
PLoS One. 2019 Jan 23;14(1):e0211188. doi: 10.1371/journal.pone.0211188. eCollection 2019.
REAC technology as optimizer of stallion spermatozoa liquid storage. Berlinguer F, Pasciu V, Succu S, Cossu I, Caggiu S, Addis D, Castagna A, Fontani V, Rinaldi S, Passino ES. Reprod Biol Endocrinol. 2017 Feb 8;15(1):11. doi: 10.1186/s12958-017-0229-6.
REAC technology and hyaluron synthase 2, an interesting network to slow down stem cell senescence. Maioli M, Rinaldi S, Pigliaru G, Santaniello S, Basoli V, Castagna A, Fontani V, Ventura C. Sci Rep. 2016 Jun 24;6:28682.
Neurological morphofunctional differentiation induced by REAC technology in PC12. A neuro protective model for Parkinson's disease. Maioli M, Rinaldi S, Migheli R, Pigliaru G, Rocchitta G, Santaniello S, Basoli V, Castagna A, Fontani V, Ventura C, Serra PA. Sci Rep. 2015 May 15;5:10439. doi: 10.1038/srep10439.
Stem cell senescence. Effects of REAC technology on telomerase-independent and telomerase-dependent pathways. Rinaldi S, Maioli M, Pigliaru G, Castagna A, Santaniello S, Basoli V, Fontani V, Ventura C. Sci Rep. 2014 Sep 16;4:6373. doi: 10.1038/srep06373.
Long-lasting changes in brain activation induced by a single REAC technology pulse in Wi-Fi bands. Randomized double-blind fMRI qualitative study. Rinaldi S, Mura M, Castagna A, Fontani V. Sci Rep. 2014 Jul 11;4:5668. doi: 10.1038/srep05668.
Motor Effects of Radio Electric Asymmetric Conveyer in Alzheimer's Disease: Results from a Cross-Over Trial. Olazarán J, González B, Osa-Ruiz E, Felipe-Ruiz S, Boyano I, Fontani V, Castagna A, Mendoza C, Zea MA, Frades B, Rinaldi S, Martínez-Martín P. J Alzheimers Dis. 2014 May 30.
Radio electric asymmetric conveyed fields and human adipose-derived stem cells obtained with a non-enzymatic method and device: a novel approach to multipotency. Maioli M, Rinaldi S, Santaniello S, Castagna A, Pigliaru G, Delitala A, Bianchi F, Tremolada C, Fontani V, Ventura C. Cell Transplant. 2013 Aug 30. doi: 10.3727/096368913X672037. [Epub ahead of print]
Effects of regenerative radioelectric asymmetric conveyer treatment on human normal and osteoarthritic chondrocytes exposed to IL-1β. A biochemical and morphological study.
Collodel G, Fioravanti A, Pascarelli NA, Lamboglia A, Fontani V, Maioli M, Santaniello S, Pigliaru G, Castagna A, Moretti E, Iacoponi F, Rinaldi S, Ventura C.Clin Interv Aging. 2013;8:309-16. doi: 10.2147/CIA.S42229. Epub 2013 Mar 19.
Anti-senescence efficacy of radio-electric asymmetric conveyer technology. Maioli M, Rinaldi S, Santaniello S, Castagna A, Pigliaru G, Delitala A, Lotti Margotti M, Bagella L, Fontani V, Ventura C. Age (Dordr). 2013 May 9. [Epub ahead of print]
Motor Effects of REAC in Advanced Alzheimer's Disease: Results From a Pilot Trial. Olazarán J, González B, López J, Castagna A, Osa-Ruiz E, Herrero-Cano V, Agüera-Ortiz L, Rinaldi S, Martínez-Martín P. J Alzheimers Dis. 2013 Apr 19.
Physical reparative treatment in reptiles. Rinaldi S, Iannaccone M, Magi GE, Costantini E, Castagna A, Sanna Passino E, Maioli M, Fontani V. BMC Vet Res. 2013 Feb 26;9(1):39. doi: 10.1186/1746-6148-9-39. PMID: 23442770 [PubMed - in process]
The effect of radio electric asymmetric conveyer treatment on sperm parameters of subfertile stallions: a pilot study. Collodel G, Rinaldi S, Moretti E, Fontani V, Castagna A, Iacoponi F, Terzuoli G, Cubeddu F, Careddu GM, Cossu I, Passino ES. Reprod Biol. 2012 Nov;12(3):277-84. doi: 10.1016/j.repbio.2012.09.007. Epub 2012 Oct 22
Radio Electric Conveyed Fields Directly Reprogram Human Dermal-Skin Fibroblasts Towards Cardiac-, Neuronal-, and Skeletal Muscle-Like Lineages. Maioli M, Rinaldi S, Santaniello S, Castagna A, Pigliaru G, Gualini S, Cavallini C, Fontani V, Ventura C. Cell Transplant. 2012 Oct 2. doi: 10.3727/096368912X657297. [Epub ahead of print]
Regenerative treatment using a radioelectric asymmetric conveyor as a novel tool in antiaging medicine: an in vitro beta-galactosidase study. Rinaldi S, Maioli M, Santaniello S, Castagna A, Pigliaru G, Gualini S, Margotti ML, Carta A, Fontani V, Ventura C. Clin Interv Aging. 2012;7:191-4. Epub 2012 Jun 29.
Preliminary pilot fMRI study of neuropostural optimization with a noninvasive asymmetric radioelectric brain stimulation protocol in functional dysmetria. Mura M, Castagna A, Fontani V, Rinaldi S. Neuropsychiatr Dis Treat. 2012;8:149-54. Epub 2012 Apr 4.
Neuropsychophysical optimization by REAC technology in the treatment of: sense of stress and confusion. Psychometric evaluation in a randomized, single blind, sham-controlled naturalistic study. Fontani V, Aravagli L, Margotti ML, Castagna A, Mannu P, Rinaldi S. Patient Prefer Adherence. 2012;6:195-9. Epub 2012 Mar 19.
Noninvasive radioelectric asymmetric conveyor brain stimulation treatment improves balance in individuals over 65 suffering from neurological diseases: pilot study. Fontani V, Rinaldi S, Castagna A, Margotti ML. Ther Clin Risk Manag. 2012;8:73-8. Epub 2012 Feb 17.
Social anxiety disorder: radio electric asymmetric conveyor brain stimulation versus sertraline. Fontani V, Mannu P, Castagna A, Rinaldi S. Patient Prefer Adherence. 2011;5:581-6. Epub 2011 Nov 22.
Noninvasive brain stimulation by radioelectric asymmetric conveyor in the treatment of agoraphobia: open-label, naturalistic study. Mannu P, Rinaldi S, Fontani V, Castagna A, Margotti ML. Patient Prefer Adherence. 2011;5:575-80. Epub 2011 Nov 18. PMID: 22163156 [PubMed] Free PMC Article. Related citations
Brain activity modification produced by a single radioelectric asymmetric brain stimulation pulse: a new tool for neuropsychiatric treatments. Preliminary fMRI study.
Rinaldi S, Fontani V, Castagna A. Neuropsychiatr Dis Treat. 2011;7:649-54. Epub 2011 Oct 28.
Noninvasive radioelectric asymmetric brain stimulation in the treatment of stress-related pain and physical problems: psychometric evaluation in a randomized, single-blind placebo-controlled, naturalistic study. Fontani V, Rinaldi S, Aravagli L, Mannu P, Castagna A, Margotti ML. Int J Gen Med. 2011;4:681-6. Epub 2011 Sep 22.
Radio Frequency Energy Loop Primes Cardiac, Neuronal, and Skeletal Muscle Differentiation in Mouse Embryonic Stem Cells: A New Tool For Improving Tissue Regeneration.
Maioli M, Rinaldi S, Santaniello S, Castagna A, Pigliaru G, Gualini S, Fontani V, Ventura C. Cell Transplant. 2011 Sep 22. doi: 10.3727/096368911X600966. [Epub ahead of print]
Radioelectric asymmetric stimulation of tissues as treatment for post-traumatic injury symptoms. Fontani V, Castagna A, Mannu P, Rinaldi S. Int J Gen Med. 2011;4:627-34. Epub 2011 Aug 26.
Radio electric tissue optimization in the treatment of surgical wounds. Castagna A, Fontani V, Rinaldi S, Mannu P. Clin Cosmet Investig Dermatol. 2011;4:133-7. Epub 2011 Aug 25.
Radioelectric brain stimulation in the treatment of generalized anxiety disorder with comorbid major depression in a psychiatric hospital: a pilot study. Olivieri EB, Vecchiato C, Ignaccolo N, Mannu P, Castagna A, Aravagli L, Fontani V, Rinaldi S. Neuropsychiatr Dis Treat. 2011;7:449-55. Epub 2011 Aug 4.
Long-term treatment of bipolar disorder with a radioelectric asymmetric conveyor. Mannu P, Rinaldi S, Fontani V, Castagna A. Neuropsychiatr Dis Treat. 2011;7:373-9. Epub 2011 Jun 15.
Radio electric asymmetric brain stimulation in the treatment of behavioral and psychiatric symptoms in Alzheimer disease. Mannu P, Rinaldi S, Fontani V, Castagna A. Clin Interv Aging. 2011;6:207-11. Epub 2011 Jul 26.
Comparison of two treatments for coxarthrosis: local hyperthermia versus radio electric asymmetrical brain stimulation. Castagna A, Rinaldi S, Fontani V, Mannu P, Margotti ML. Clin Interv Aging. 2011;6:201-6. Epub 2011 Jul 25.
Radioelectric asymmetric brain stimulation and lingual apex repositioning in patients with atypical deglutition. Castagna A, Rinaldi S, Fontani V, Mannu P. J Multidiscip Healthc. 2011;4:209-13. Epub 2011 Jun 21.
Stress-related psycho-physiological disorders: randomized single blind placebo controlled naturalistic study of psychometric evaluation using a radio electric asymmetric treatment.
Rinaldi S, Fontani V, Aravagli L, Mannu P, Castagna A, Margotti ML, Rosettani B. Health Qual Life Outcomes. 2011 Jul 19;9:54.
Does osteoarthritis of the knee also have a psychogenic component? Psycho-emotional treatment with a radio-electric device vs. intra-articular injection of sodium hyaluronate: an open-label, naturalistic study. Castagna A, Rinaldi S, Fontani V, Aravagli L, Mannu P, Margotti ML. Acupunct Electrother Res. 2010;35(1-2):1-16.
Radio electric treatment vs. Es-Citalopram in the treatment of panic disorders associated with major depression: an open-label, naturalistic study. Mannu P, Rinaldi S, Fontani V, Castagna A, Margotti ML. Acupunct Electrother Res. 2009;34(3-4):135-49.