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DEPARTMENT

REGENERATIVE MEDICINE

The Department of Regenerative Medicine the Rinaldi Fontani Institute is dedicated to the research and development of innovative therapies in the field of regenerative medicine, with a particular focus on the applications of REAC TECHNOLOGY® (Radio Electric Asymmetric Conveyer). Through years of studies and research, the Institute has developed and refined a number of specific treatments that have proven effective in combating various degenerative and neurodegenerative diseases.

Treatments with REAC TECHNOLOGY®, studied and developed at our Institute, are carried out in dedicated rooms, ensuring an optimal and specialized environment for their development. This attention to the therapeutic context ensures an accurate and personalised application of the protocols, best supporting cellular and tissue repair and regeneration processes.

It is important to underline that these regenerative medicine treatments are exclusively available at the Rinaldi Fontani Institute, reflecting the commitment and expertise that characterise our approach. In fact, the Institute has developed a unique path of research and therapeutic application, which has led to results documented in numerous scientific publications. Many of these studies have been published in international journals and are indexed in PubMed, highlighting the Institute’s significant contribution to the scientific community.

Through an approach based on scientific evidence and advanced protocols, the Department of Regenerative Medicine continues to work to develop increasingly effective therapies, offering concrete support to people facing degenerative conditions, in an exclusive and highly specialized environment.

Dr. Vania Fontani

Doctor Surgeon
Neurophysiopathologist
Physical Medicine and Rehabilitation
Master II Liv. in Neuro Psycho Pathophysiology and Optimization Neuro Physical Psycho

Register of Professional Association of Physicians of Florence and Province No. 9096

Co-founder and Health Director of the Rinaldi Fontani Institute

Co-founder and Scientific Director of IRF Shanghai Medical Science Co., Ltd – Shanghai, China

President of the Italian Society of Neuro-Psycho-Physical Optimization (SONC)

Vice President of the International Society of Neuroscience for Neuro Psycho Physical Optimization (ISNPO)

 

Professional path:

Since 1989 he has been a lecturer in second-level university master’s degrees and university master’s courses on adaptive neurophysiopathology and neuro-psycho-physical optimisation at the faculties of Medicine and Surgery G. D’Annunzio – Chieti, Tor Vergata – Rome and Florence.
Speaker at national and international congresses.
In his research activity he defined four international patents concerning the technology of conveyed radio fields and the modulation of cellular reprogramming through these. It also defined a national patent for a measuring instrument for anatomical-functional misalignments.

 

Publications in international peer reviewed scientific journals indexed on PubMed:

Long-Lasting Efficacy of Radio Electric Asymmetric Conveyer Neuromodulation Treatment on Functional Dysmetria, an Adaptive Motor Behavior. Fontani V, Rinaldi A, Rinaldi C, et al. Cureus. 2022 Jun 8; 14(6): e25768. doi:10.7759/cureus.25768

Radio Electric Asymmetric Conveyer Tissue Reparative Treatment on Post-surgical Breast Skin Necrosis. A Report of Four Cases. Fontani V, Coelho Pereira JA, Rinaldi S. Cureus. 2022 Jun 5;14(6):e25666. doi: 10.7759/cureus.25666. eCollection 2022 Jun.

Radio Electric Asymmetric Conveyer Reparative Effects on Muscle Injuries: A Report of Two Cases. Chestnut A, Fontani V, Rinaldi S. Cureus. 2022 May 11;14(5):e24904. doi: 10.7759/cureus.24904. eCollection 2022 May.



REAC-induced endogenous bioelectric currents in the treatment of venous ulcers: a three-arm randomized controlled prospective study. Elio C, Fontani V, Rinaldi S, Gasbarro V. Acta Dermatovenerol Alp Pannonica Adriat. 2020 Sep;29(3):109-113. PMID: 32975296.

REAC neurobiological treatments in acute post-traumatic knee medial collateral ligament lesion. Barcessat ARP, Bittencourt MN, Pereira JAC, Castagna A, Fontani V, Rinaldi S. Heliyon. 2020 Jul 24;6(7):e04539. doi: 10.1016/j.heliyon.2020.e04539. PMID: 32743108; PMCID: PMC7385461.

Radio electric asymmetric conveyer neuromodulation in depression, anxiety, and stress. Rinaldi A, Rinaldi C, Coelho Pereira JA, Lotti Margotti M, Bittencourt MN, Barcessat ARP, Fontani V, Rinaldi S. Neuropsychiatric Disease and Treatment 2019:15 469?480.

Physical stimulation by REAC and BMP4/WNT-1 inhibitor synergistically enhance cardiogenic commitment in iPSCs. Basoli V, Santaniello S, Rinaldi S, Fontani V, Pigliaru G, Wieser M, Strajeriu A, Castagna A, Redl H, Ventura C, Grillari R, Maioli M.
PLoS One. 2019 Jan 23;14(1):e0211188. doi: 10.1371/journal.pone.0211188. eCollection 2019.

Radio Electric Asymmetric Conveyer (REAC) technology to obviate loss of T cell responsiveness under simulated microgravity. Rinaldi S, Meloni MA, Galleri G, Maioli M, Pigliaru G, Cugia G, Santaniello S, Castagna A, Fontani V. PLoS One. 2018 Jul 6;13(7):e0200128. doi: 10.1371/journal.pone.0200128. eCollection 2018.

REAC neuromodulation treatments in subjects with severe socio-economic and cultural hardship in the Brazilian state of Pará: A family observational pilot study. Coelho Pereira JA, Rinaldi A, Fontani V, Rinaldi S. Neuropsychiatr Dis Treat. 2018 Apr 16;14:1047-1054.
doi: 10.2147/NDT.S161646. eCollection 2018.

Radio Electric Asymmetric Conveyer Technology Modulates Neuroinflammation in a Mouse Model of Neurodegeneration.
Panaro MA, Aloisi A, Nicolardi G, Lofrumento DD, De Nuccio F, La Pesa V, Cianciulli A, Rinaldi R, Calvello R, Fontani V, Rinaldi S. Neurosci Bull. 2017 Nov 10. doi: 10.1007/s12264-017-0188-0.

REAC technology as optimizer of stallion spermatozoa liquid storage. Berlinguer F, Pasciu V, Succu S, Cossu I, Caggiu S, Addis D, Castagna A, Fontani V, Rinaldi S, Passino ES. Reprod Biol Endocrinol. 2017 Feb 8;15(1):11. doi: 10.1186/s12958-017-0229-6.

REAC technology modifies pathological neuroinflammation and motor behaviour in an Alzheimer’s disease mouse model. Lorenzini L, Giuliani A, Sivilia S, Baldassarro VA, Fernandez M, Margotti ML, Giardino L, Fontani V, Rinaldi S, Calzà L. Sci Rep. 2016 Nov 18;6:37483. doi: 10.1038/srep37483.

REAC technology and hyaluron synthase 2, an interesting network to slow down stem cell senescence. Maioli M, Rinaldi S, Pigliaru G, Santaniello S, Basoli V, Castagna A, Fontani V, Ventura C. Sci Rep. 2016 Jun 24;6:28682.

Osteogenesis from Dental Pulp Derived Stem Cells: A Novel Conditioned Medium Including Melatonin within a Mixture of Hyaluronic, Butyric, and Retinoic Acids.Maioli M, Basoli V, Santaniello S, Cruciani S, Delitala AP, Pinna R, Milia E, Grillari-Voglauer R, Fontani V, Rinaldi S, Muggironi R, Pigliaru G, Ventura C. Stem Cells Int. 2016;2016:2056416. doi: 10.1155/2016/2056416. Epub 2016 Jan 10.

Electrophysiological effects of non-invasive Radio Electric Asymmetric Conveyor (REAC) on thalamocortical neural activities and perturbed experimental conditions. Zippo AG, Rinaldi S, Pellegata G, Caramenti GC, Valente M, Fontani V, Biella GE. Ski Rep. 2015 Dec 11;5:18200.

Neurological morphofunctional differentiation induced by REAC technology in PC12. A neuro protective model for Parkinson’s disease. Maioli M, Rinaldi S, Migheli R, Pigliaru G, Rocchitta G, Santaniello S, Basoli V, Castagna A, Fontani V, Ventura C, Serra PA. Ski Rep. 2015 May 15;5:10439. doi: 10.1038/srep10439.

Radio electric asymmetric conveyer: a novel neuromodulation technology in Alzheimer’s and other neurodegenerative diseases. Rinaldi S, Calzà L, Giardino L, Biella GE, Zippo AG, Fontani V. Front Psychiatry. 2015 Feb 17;6:22.

Stem cell senescence. Effects of REAC technology on telomerase-independent and telomerase-dependent pathways. Rinaldi S, Maioli M, Pigliaru G, Castagna A, Santaniello S, Basoli V, Fontani V, Ventura C. Sci Rep. 2014 Sep 16;4:6373.

Long-lasting changes in brain activation induced by a single REAC technology pulse in Wi-Fi bands. Randomized double-blind fMRI qualitative study. Rinaldi S, Mura M, Castagna A, Fontani V. Sci Rep. 2014 Jul 11;4:5668. doi: 10.1038/srep05668.

Motor Effects of Radio Electric Asymmetric Conveyer in Alzheimer’s Disease: Results from a Cross-Over Trial. Olazarán J, González B, Osa-Ruiz E, Felipe-Ruiz S, Boyano I, Fontani V, Castagna A, Mendoza C, Zea MA, Frades B, Rinaldi S, Martínez-Martín P. J Alzheimers Dis. 2014 May 30.

Radio electric asymmetric conveyed fields and human adipose-derived stem cells grown with a non-enzymatic method and device: A novel approach to multipotency. Maioli M, Rinaldi S, Santaniello S, Castagna A, Pigliaru G, Delitala A, Bianchi F, Tremolada C, Fontani V, Ventura C. Cell Transplant. 2013 Aug 30.

Effects of regenerative radioelectric asymmetric conveyer treatment on human normal and osteoarthritic chondrocytes exposed to IL-1?. A biochemical and morphological study.
Collodel G, Fioravanti A, Pascarelli NA, Lamboglia A, Fontani V, Maioli M, Santaniello S, Pigliaru G, Castagna A, Moretti E, Iacoponi F, Rinaldi S, Ventura C.Clin Interv Aging. 2013;8:309-16. doi: 10.2147/CIA.S42229. Epub 2013 Mar 19.

Anti-senescence efficacy of radio-electric asymmetric conveyer technology. Maioli M, Rinaldi S, Santaniello S, Castagna A, Pigliaru G, Delitala A, Lotti Margotti M, Bagella L, Fontani V, Ventura C. Age (Dordr). 2013 May 9.

Physical reparative treatment in reptiles.
Rinaldi S, Iannaccone M, Magi GE, Costantini E, Castagna A, Sanna Passino E, Maioli M, Fontani V.
BMC Vet Res. 2013 Feb 26;9(1):39.

The effect of radio electric asymmetric conveyer treatment on sperm parameters of subfertile stallions: A pilot study. Collodel G, Rinaldi S, Moretti E, Fontani V, Castagna A, Iacoponi F, Terzuoli G, Cubeddu F, Careddu GM, Cossu I, Passino ES. Reprod Biol. 2012 Nov;12(3):277-84. Epub 2012 Oct 22.

Radio Electric Conveyed Fields Directly Reprogram Human Dermal-Skin Fibroblasts Towards Cardiac-, Neuronal-, and Skeletal Muscle-Like Lineages. Maioli M, Rinaldi S, Santaniello S, Castagna A, Pigliaru G, Gualini S, Cavallini C, Fontani V, Ventura C. Cell Transplant. 2012 Oct 2.

Regenerative treatment using a radioelectric asymmetric conveyor as a novel tool in antiaging medicine: an in vitro beta-galactosidase study. Rinaldi S, Maioli M, Santaniello S, Castagna A, Pigliaru G, Gualini S, Margotti ML, Carta A, Fontani V, Ventura C. Clin Interv Aging. 2012;7:191-4. Epub 2012 Jun 29.

Preliminary pilot fMRI study of neuropostural optimization with a noninvasive asymmetric radioelectric brain stimulation protocol in functional dysmetry. Mura M, Chestnut A, Fontani V, Rinaldi S. Neuropsychiatr Dis Treat. 2012;8:149-54. Epub 2012 Apr 4.

Neuropsychophysical optimization by REAC technology in the treatment of: Sense of stress and confusion. Psychometric evaluation in a randomized, single blind, sham-controlled naturalistic study. Fontani V, Aravagli L, Margotti ML, Castagna A, Mannu P, Rinaldi S. Patient Prefer Adherence. 2012;6:195-9. Epub 2012 Mar 19.

Noninvasive radioelectric asymmetric conveyor brain stimulation treatment improves balance in individuals over 65 suffering from neurological diseases: Pilot study. Fontani V, Rinaldi S, Castagna A, Margotti ML. Ther Clin Risk Manag. 2012;8:73-8. Epub 2012 Feb 17.

Social Anxiety Disorder: radio electric asymmetric conveyor brain stimulation versus sertraline. Fontani V, Mannu P, Castagna A, Rinaldi S. Patient Prefer Adherence. 2011;5:581-6. Epub 2011 Nov 22.

Noninvasive brain stimulation by radioelectric asymmetric conveyor in the treatment of agoraphobia: open-label, naturalistic study. Mannu P, Rinaldi S, Fontani V, Castagna A, Margotti ML. Patient Prefer Adherence. 2011;5:575-80. Epub 2011 Nov 18.

Brain activity modification produced by a single radioelectric asymmetric brain stimulation pulse: a new tool for neuropsychiatric treatments. Preliminary fMRI study. Rinaldi S, Fontani V, Chestnut A. Neuropsychiatr Dis Treat. 2011;7:649-54. Epub 2011 Oct 28.

Noninvasive radioelectric asymmetric brain stimulation in the treatment of stress-related pain and physical problems: Psychometric evaluation in a randomized, single-blind placebo-controlled, naturalistic study. Fontani V, Rinaldi S, Aravagli L, Mannu P, Castagna A, Margotti ML. Int J Gen Med. 2011;4:681-6. Epub 2011 Sep 22.

Radio Frequency Energy Loop Primes Cardiac, Neuronal, and Skeletal Muscle Differentiation in Mouse Embryonic Stem Cells: A New Tool for Improving Tissue Regeneration.
Maioli M, Rinaldi S, Santaniello S, Castagna A, Pigliaru G, Gualini S, Fontani V, Ventura C. Cell Transplant. 2011 Sep 22.

Radioelectric asymmetric stimulation of tissues as treatment for post-traumatic injury symptoms. Fontani V, Castagna A, Mannu P, Rinaldi S. Int J Gen Med. 2011;4:627-34. Epub 2011 Aug 26.

Radio electric tissue optimization in the treatment of surgical wounds. Chestnut A, Fontani V, Rinaldi S, Mannu P. Clin Cosmet Investig Dermatol. 2011;4:133-7. Epub 2011 Aug 25.

Radioelectric brain stimulation in the treatment of generalized anxiety disorder with comorbid major depression in a psychiatric hospital: A pilot study. Olivieri EB, Vecchiato C, Ignaccolo N, Mannu P, Castagna A, Aravagli L, Fontani V, Rinaldi S. Neuropsychiatr Dis Treat. 2011;7:449-55. Epub 2011 Aug 4.

Long-term treatment of bipolar disorder with a radioelectric asymmetric conveyor. Mannu P, Rinaldi S, Fontani V, Chestnut A .Neuropsychiatr Dis Treat. 2011;7:373-9. Epub 2011 Jun 15.

Radio electric asymmetric brain stimulation in the treatment of behavioral and psychiatric symptoms in Alzheimer's disease. Mannu P, Rinaldi S, Fontani V, Castagna A.
Clin Interv Aging. 2011;6:207-11. Epub 2011 Jul 26.

Comparison of two treatments for coxarthrosis: local hyperthermia versus radio electric asymmetrical brain stimulation. Chestnut A, Rinaldi S, Fontani V, Mannu P, Margotti ML.
Clin Interv Aging. 2011;6:201-6. Epub 2011 Jul 25.

Radioelectric asymmetric brain stimulation and lingual apex repositioning in patients with atypical deglutition. Chestnut A, Rinaldi S, Fontani V, Mannu P. J Multidiscip Healthc. 2011;4:209-13. Epub 2011 Jun 21.

Stress-related psycho-physiological disorders: randomized single blind placebo controlled naturalistic study of psychometric evaluation using a radio electric asymmetric treatment.
Rinaldi S, Fontani V, Aravagli L, Mannu P, Castagna A, Margotti ML, Rosettani B. Health Qual Life Outcomes. 2011 Jul 19;9:54.

Psychological and symptomatic stress-related disorders with radio-electric treatment: Psychometric evaluation. Rinaldi S, Fontani, V., Aravagli, L., Lotti Margotti, M. Stress and Health. 2010;26(5):350-358.

A new approach on stress-related depression & anxiety: Neuro-Psycho-Physical-Optimization with Radio Electric Asymmetric-Conveyer. Rinaldi S, Fontani V, Moretti E, Rosettani B, Aravagli L, Saragò G, Collodel G. Indian J Med Res. 2010 Aug;132:189-94.

Does osteoarthritis of the knee also have a psychogenic component? Psycho-emotional treatment with a radio-electric device vs. intra-articular injection of sodium hyaluronate: an open-label, naturalistic study. Chestnut A, Rinaldi S, Fontani V, Aravagli L, Mannu P, Margotti ML. Acupunct Electrother Res. 2010;35(1-2):1-16.

Psychometric evaluation of a radio electric auricular treatment for stress related disorders: a double-blinded, placebo-controlled pilot study. Rinaldi S, Fontani V, Aravagli L, Mannu P. Health Qual Life Outcomes. 2010 Mar 20;8:31.

Radio electric treatment vs. Es-Citalopram in the treatment of panic disorders associated with major depression: an open-label, naturalistic study. Mannu P, Rinaldi S, Fontani V, Castagna A, Margotti ML. Acupunct Electrother Res. 2009;34(3-4):135-49.

Effect of emotional stress on sperm quality. Collodel G, Moretti E, Fontani V, Rinaldi S, Aravagli L, Saragò G, Capitani S, Anichini C. Indian J Med Res. 2008 Sep;128(3):254-61.

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